List of cutaneous conditions

See also: Cutaneous conditions, Category:Cutaneous conditions, and ICD-10 Chapter XII: Diseases of the skin and subcutaneous tissue
Young child with a red rash covering face, chest, shoulders, and arms.
Measles

There are many conditions of or affecting the human integumentary system—the organ system that covers the entire surface of the body and is composed of skin, hair, nails, and related muscle and glands.[1] The major function of this system is as a barrier against the external environment.[2] The skin weighs an average of four kilograms, covers an area of two square meters, and is made of three distinct layers: the epidermis, dermis, and subcutaneous tissue.[1] There are two main types of human skin: glabrous skin, the non-hairy skin on the palms and soles (also referred to as the "palmoplantar" surfaces), and hair-bearing skin.[3] Within the latter type, there are hairs in structures called pilosebaceous units, each with hair follicle, sebaceous gland, and associated arrector pili muscle.[4] In the embryo, the epidermis, hair, and glands form from the ectoderm, which is chemically influenced by the underlying mesoderm that forms the dermis and subcutaneous tissues.[5][6][7]

The epidermis is the most superficial layer of skin, a squamous epithelium with several strata: the stratum corneum, stratum lucidum, stratum granulosum, stratum spinosum, and stratum basale.[8] Nourishment is provided to these layers via diffusion from the dermis, since the epidermis is without direct blood supply. The epidermis contains four cell types: keratinocytes, melanocytes, Langerhans cells, and the Merkel cell. Of these, keratinocytes are the major component, constituting roughly 95 percent of the epidermis.[3] This stratified squamous epithelium is maintained by cell division within the stratum basale, in which differentiating cells slowly displace outwards through the stratum spinosum to the stratum corneum, where cells are continually shed from the surface.[3] In normal skin, the rate of production equals the rate of loss; it takes about two weeks for a cell to migrate from the basal cell layer to the top of the granular cell layer, and an additional two weeks to cross the stratum corneum.[9]

The dermis is the layer of skin between the epidermis and subcutaneous tissue, and comprises two sections, the papillary and reticular dermis.[10] The superficial papillary dermis interdigitates with the overlying rete ridges of the epidermis, between which the two layers interact through the basement membrane zone.[10] Structural components of the dermis are collagen, elastic fibers, and extrafibrillar matrix (previously called ground substance).[10] Within these components are the pilosebaceous units, arrector pili muscles, and the eccrine and apocrine glands.[8] The dermis contains two vascular networks that run parallel to the skin surface—one superficial and one deep plexus—which are connected by vertical communicating vessels.[8][11] The function of blood vessels within the dermis is fourfold: to supply nutrition, to regulate temperature, to modulate inflammation, and to participate in wound healing.[12][13]

The subcutaneous tissue is a layer of fat between the dermis and underlying fascia.[14] This tissue may be further divided into two components, the actual fatty layer, or panniculus adiposus, and a deeper vestigial layer of muscle, the panniculus carnosus.[3] The main cellular component of this tissue is the adipocyte, or fat cell.[14] The structure of this tissue is composed of septal (i.e. linear strands) and lobular compartments, which differ in microscopic appearance.[8] Functionally, the subcutaneous fat insulates the body, absorbs trauma, and serves as a reserve energy source.[14]

Conditions of the human integumentary system constitute a broad spectrum of diseases, also known as dermatoses, as well as several nonpathologic states (like, in certain circumstances, melanonychia and racquet nails).[15][16] While only a small number of skin diseases account for most visits to the physician, thousands of skin conditions have been described.[14] Classification of these conditions often presents many nosological challenges, since underlying etiologies and pathogenetics are often not known.[16][17] Therefore, most current textbooks present a classification based on location (for example, conditions of the mucous membrane), morphology (chronic blistering conditions), etiology (skin conditions resulting from physical factors), and so on.[18] Clinically, the diagnosis of any particular skin condition is made by gathering pertinent information regarding the presenting skin lesion(s), including the location (such as arms, head, legs), symptoms (pruritus, pain), duration (acute or chronic), arrangement (solitary, generalized, annular, linear), morphology (macules, papules, vesicles), and color (red, blue, brown, black, white, yellow).[19] The diagnosis of a many conditions often also requires a skin biopsy which yields histologic information[20][21] that can be correlated with the clinical presentation and any laboratory data.[22][23]

Contents

Acneiform eruptions

Acneiform eruptions are caused by changes in the pilosebaceous unit.[24][25]

Autoinflammatory syndromes

Autoinflammatory syndromes are a group of inherited disorders characterized by bouts of inflammatory skin lesions and periodic fevers.[26][27]

Chronic blistering

Chronic blistering cutaneous conditions have a prolonged course and present with vesicles and bullae.[28][29][30]

Conditions of the mucous membranes

Conditions of the mucous membranes involve the moist linings of the eyes, nose, mouth, genitals, and anus.[31]

Conditions of the skin appendages

Conditions of the skin appendages are those affecting the glands of the skin, hair, nails, and arrector pili muscles.[1]

Conditions of the subcutaneous fat

Conditions of the subcutaneous fat are those affecting the layer of adipose tissue that lies between the dermis and underlying fascia.[32][33][34][35]

Congenital anomalies

Cutaneous congenital anomalies are a diverse group of disorders that result from faulty morphogenesis, the biological process that forms the shape of a human body.[36]

Connective tissue diseases

Connective tissue diseases are caused by a complex array of autoimmune responses that target or affect collagen or ground substance.[37]

Abnormalities of dermal fibrous and elastic tissue

Abnormalities of dermal fibrous and elastic tissue are caused by problems in the regulation of collagen synthesis and/or degradation.[38]

Fuzzy red lines on an abdomen
Striae distensae

Dermal and subcutaneous growths

Dermal and subcutaneous growths result from (1) reactive or neoplastic proliferation of cellular components of the dermis or subcutaneous tissue, or (2) neoplasms invading or aberrantly present in the dermis.[1]

Dermatitis

Dermatitis is a general term for "inflammation of the skin."[39]

Atopic

Atopic dermatitis is a chronic dermatitis associated with a hereditary tendency to develop allergies to food and inhalant substances.[40][41]

Contact

Contact dermatitis is caused by certain substances coming in contact with the skin.[42][43]

Eczema

Eczema refers to a broad range of conditions that begin as spongiotic dermatitis and may progress to a lichenified stage.[44]

Small blisters and crusting on the distal fingertips
Dyshidrosis

Pustular

Pustular dermatitis is an inflammation of the skin that presents with pustular lesions.[45]

Seborrheic

Seborrheic dermatitis is a chronic, superficial, inflammatory disease characterized by scaling on an erythematous base.[46]

Disturbances of pigmentation

Disturbances of human pigmentation, either loss or reduction, may be related to loss of melanocytes or the inability of melanocytes to produce melanin or transport melanosomes correctly.[47][48][49]

Drug eruptions

Drug eruptions are adverse drug reactions that present with cutaneous manifestations.[50][51][52]

Endocrine-related

Endocrine conditions often present with cutaneous findings as the skin interacts with the endocrine system in many ways.[53][54]

Eosinophilic

Eosinophilic cutaneous conditions encompass a wide variety of diseases that are characterized histologically by the presence of eosinophils in the inflammatory infiltrate and/or evidence of eosinophil degranulation.[55][56]

Epidermal nevi, neoplasms, cysts

Epidermal nevi, neoplasms, cysts are skin lesions that develop from the epidermal layer of the skin.[8]

Erythemas

Erythemas are reactive skin conditions in which there is blanchable redness.[1][9]

Genodermatoses

Genodermatoses are inherited genetic skin conditions often grouped into three categories: chromosomal, single gene, and polygenetic.[57][58]

Infection-related

Infection-related cutaneous conditions may be caused by bacteria, fungi, yeast, viruses, and/or parasites.[59]

Bacterium-related

Bacterium-related cutaneous conditions often have distinct morphologic characteristics that may be an indication of a generalized systemic process or simply an isolated superficial infection.[59][60]

Mycobacterium-related

Mycobacterium-related cutaneous conditions are caused by mycobacterium infections.[59][61]

Mycosis-related

Mycosis-related cutaneous conditions are caused by fungi or yeasts, and may present as either a superficial or deep infection of the skin, hair, and/or nails.[59]

Parasitic infestations, stings, and bites

Parasitic infestations, stings, and bites in humans are caused by several groups of animals belonging to the following phyla: Annelida, Arthropoda, Bryozoa, Chordata, Cnidaria, Cyanobacteria, Echinodermata, Nemathelminthes, Platyhelminthes, and Protozoa.[59]

Virus-related

Virus-related cutaneous conditions are caused by two main groups of viruses–DNA and RNA types–both of which are obligatory intracellular parasites.[59]

Lichenoid eruptions

Lichenoid eruptions are dermatoses related to the unique, common inflammatory disorder lichen planus, which affects the skin, mucous membranes, nails, and hair.[62][63][64]

Lymphoid-related

Lymphoid-related cutaneous conditions are a group of disorders characterized by collections of lymphocyte cells within the skin.[65]

Melanocytic nevi and neoplasms

Melanocytic nevi and neoplasms are caused by either a proliferation of (1) melanocytes, or (2) nevus cells, a form of melanocyte, but which lack dendritic processes.[66]

Monocyte- and macrophage-related

Monocyte- and macrophage-related cutaneous conditions are characterized histologically by infiltration of the skin by monocyte and/or macrophage cells,[10] often divided into several categories, including granulomatous disease,[67] histiocytoses,[68] and sarcoidosis.[69]

Mucinoses

Mucinoses are a group of conditions caused by dermal fibroblasts producing abnormally large amounts of mucopolysaccharides.[31]

Multiple, brownish colored patches of skin on an adult arm
Scleroderma

Neurocutaneous

Neurocutaneous conditions are due organic nervous system disease or are psychiatric in etiology.[70][71]

Noninfectious immunodeficiency-related

Noninfectious immunodeficiency-related cutaneous conditions are caused by T-cell and/or B-cell dysfunction.[72][73]

Nutrition-related

Nutrition-related cutaneous conditions are caused by malnutrition due to an improper or inadequate diet.[74][75]

Papulosquamous hyperkeratotic

Papulosquamous hyperkeratotic cutaneous conditions are those that present with papules and scales caused by a thickening of the stratum corneum.[9]

Palmoplantar keratodermas

Palmoplantar keratodermas are a diverse group of hereditary and acquired keratodermas in which there is hyperkeratosis of the skin of the palms and soles.[76]

Bottom of an adult's foot with a thickened and scaling surface
Palmoplantar keratoderma

Pregnancy-related

Pregnancy-related cutaneous conditions are a group of skin changes observed during pregnancy.[77][78]

Pruritic

Pruritus, commonly known as itchiness, is a sensation exclusive to the skin, and characteristic of many skin conditions.[79][80]

Psoriasis

Psoriasis is a common, chronic, and recurrent inflammatory disease of the skin characterized by circumscribed, erythematous, dry, scaling plaques.[81][82][83]

Large, red, scaly plaque
Psoriasis vulgaris

Reactive neutrophilic

Reactive neutrophilic cutaneous conditions constitute a spectrum of disease mediated by neutrophils, and typically associated with underlying diseases, such as inflammatory bowel disease and hematologic malignancy.[84][85]

Multiple ulcerations with undermined edges on the adult back and upper, posterior arm
Pyoderma gangrenosum

Recalcitrant palmoplantar eruptions

Recalcitrant palmoplantar eruptions are skin conditions of the palms and soles which are resistant to treatment.[31]

Resulting from errors in metabolism

Skin conditions resulting from errors in metabolism are caused by enzymatic defects that lead to an accumulation or deficiency of various cellular components, including, but not limited to, amino acids, carbohydrates, and lipids.[16]

Resulting from physical factors

Skin conditions resulting from physical factors occur due to a number of causes, including, but not limited to, hot and cold temperatures, friction, and moisture.[31][86]

Ionizing radiation-induced

Ionizing radiation-induced cutaneous conditions result from exposure to ionizing radiation.[87]

Urticaria and angioedema

Urticaria is a vascular reaction of the skin characterized by the appearance of wheals, which are firm, elevated swelling of the skin.[88] Angioedema, which can occur alone or with urticaria, is characterized by a well-defined, edematous swelling that involves subcutaneous tissues, abdominal organs, and/or upper airway.[89]

Raised, edematous, red skin lesions on the abdomen
Acute urticaria

Vascular-related

Vascular-related cutaneous conditions result from dysfunction of the blood and/or blood vessels in the dermis, or lymphatics in the subcutaneous tissues.[9][90]

Footnotes

  1. ↑ Any given cutaneous condition is only included once within this list.
  2. ↑ Parentheticals are used to indicate other names by which a condition is known. If there are multiple alternative names for a condition, they are separated by commas within the parenthetical.
  3. ↑ Citations for any given condition name and/or alternative name(s) may be found within the condition's respective article.
  4. ↑ This list uses American English; therefore, the symbols æ and œ, which are common to British English, are not used, but, rather, simplified to a single e. For example, the spelling of nevus is favored over nævus, edema over œdema, and so forth. For more information, see American and British English differences.
  5. ↑ Non-English names are included within this list when those terms are found in English medical literature. Inclusion of acne excoriée des jeunes filles (French), frambösie (German), and parangi (Malay) represent examples of this convention.
  6. ↑ Abbreviations for condition names commonly described in medical literature with an acronym or initialism are included within this list.
  7. ↑ Within this list, the term immunoglobulin is abbreviated to Ig when used as a prefix to a specific antibody isotype (i.e. IgA, IgD, IgE, IgG, and IgM).

References

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  2. ↑ Lippens S, Hoste E, Vandenabeele P, Agostinis P, Declercq W (April 2009). "Cell death in the skin". Apoptosis 14 (4): 549–69. doi:10.1007/s10495-009-0324-z. PMID 19221876. 
  3. ↑ 3.0 3.1 3.2 3.3 Burns, Tony; et al. (2006) Rook's Textbook of Dermatology CD-ROM. Wiley-Blackwell. ISBN 1-4051-3130-6.
  4. ↑ Paus R, Cotsarelis G (1999). "The biology of hair follicles". N Engl J Med 341 (7): 491–7. doi:10.1056/NEJM199908123410706. PMID 10441606. 
  5. ↑ Goldsmith, Lowell A. (1983). Biochemistry and physiology of the skin. Oxford University Press. ISBN 0-19-261253-0. 
  6. ↑ Fuchs E (February 2007). "Scratching the surface of skin development". Nature 445 (7130): 834–42. doi:10.1038/nature05659. PMID 17314969. 
  7. ↑ Fuchs E, Horsley V (April 2008). "More than one way to skin . .". Genes Dev. 22 (8): 976–85. doi:10.1101/gad.1645908. PMID 18413712. 
  8. ↑ 8.0 8.1 8.2 8.3 8.4 Freedberg, Irwin M.; et al. (2003). Fitzpatrick's Dermatology in General Medicine. McGraw-Hill. ISBN 0-07-138076-0. 
  9. ↑ 9.0 9.1 9.2 9.3 Bolognia, Jean L.; et al. (2007). Dermatology. St. Louis: Mosby. ISBN 1-4160-2999-0. 
  10. ↑ 10.0 10.1 10.2 10.3 Rapini, Ronald P. (2005). Practical dermatopathology. Elsevier Mosby. ISBN 0-323-01198-5. 
  11. ↑ Grant-Kels JM (2007). Color Atlas of Dermatopathology (Dermatology: Clinical & Basic Science). Informa Healthcare. pp. 163. ISBN 0-8493-3794-1. 
  12. ↑ Ryan, T (1991). "Cutaneous Circulation". In Goldsmith, Lowell A. Physiology, biochemistry, and molecular biology of the skin (2nd ed.). New York: Oxford University Press. p. 1019. ISBN 0-19-505612-4. 
  13. ↑ Swerlick RA, Lawley TJ (January 1993). "Role of microvascular endothelial cells in inflammation". J. Invest. Dermatol. 100 (1): 111S–115S. PMID 8423379. 
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  15. ↑ King, L.S. (1954). "What Is Disease?". Philosophy of Science 21: 193-203. 
  16. ↑ 16.0 16.1 16.2 Bluefarb, Samuel M. (1984). Dermatology. Upjohn Co. ISBN 0-89501-004-6. 
  17. ↑ Lambert WC, Everett MA (October 1981). "The nosology of parapsoriasis". J. Am. Acad. Dermatol. 5 (4): 373–95. doi:10.1016/S0190-9622(81)70100-2. PMID 7026622. 
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  37. ↑ Crofford, Leslie J.; Klippel, John H.; Weyand, Cornelia M.; Stone, John F. (2001). Primer on the rheumatic diseases. Atlanta, GA: Arthritis Foundation. ISBN 0-912423-29-3. 
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